Weight Loss:How Exercise Influences the Long-Term Efficacy of Weight Loss Drugs

Newer weight loss drugs suppress appetite and reduce food cravings, eating less food can help people lose weight. Many people lose at least 20 or more of their body weight while taking the drugs. Let’s reduce it by 30 percent.

But in the real world, despite the good effects of drugs, about half of people stop taking them within a year due to cost, side effects, or other reasons.

After this, they lose weight almost permanently. What is worrying is that people lose muscle mass and are less metabolically healthy than they were before starting the medications.

However an important new long-term study of people who used and then quit one of the weight-loss drugs suggests that exercise is also a simple, accessible way to prevent unhealthy weight gain after stopping the drugs. It is possible

Studies have also shown that people who exercised while using weight loss medication lost more weight after quitting the medication than people who did not exercise and maintained more muscle kept.

Senior author Signe Sorensen Torekov a professor of biomedical sciences at the University of Copenhagen in Denmark suggests in the new study that people who use the drugs may be able to “maintain a healthy weight” even after quitting the drugs..But exercising them can help a lot.

weight loss
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weight loss

Most obesity experts agree that the key to healthy long-term weight loss is maintenance. In the short term losing pounds is also possible for many people.

GLP-1 diabetes or weight loss drugs with brand names such as Ozempic, Vegovy, Zepbound, and Monzaro appear to work faster.

Many people lose weight rapidly with these medicines. But if they stop taking the medicine, their weight usually returns to normal almost immediately.

Torekov and his colleagues have attempted to find out.

The effort began with 195 Danish adults who were obese but had no other major health conditions. He was put on an extremely low-calorie diet under the supervision of scientists to quickly lose about 30 pounds.

Since this was a weight-maintenance study the scientists wanted them to lose weight rapidly and then proceed to a maintenance phase after that.

The researchers assigned some volunteers to start taking Saxenda, which we know as liraglutide. An early GLP-1 drug, Saxenda is made by Novo Nordisk. The company Novo Nordisk also makes two similar drugs. – Diabetes drug Ozempic and weight loss drug Vegovy.

A separate group of volunteers started the same medication but also began a supervised exercise program including twice-weekly, half-hour group spinning classes and 15 minutes of high-intensity, full-body resistance training. Do jogging or similar workouts at home. Exercise that is, people cannot talk to each other while exercising.

A control group did not exercise at all and received a placebo instead of taking liraglutide.

After a year, almost all people taking the drug maintained their weight loss or lost more weight.

However, people who combined medication and exercise had the most harm. Those taking the drug alone lost about six pounds more weight and more of those pounds were made up of fat rather than muscle.

What happened when they stopped the medicine

Those results were published by the researchers in the New England Journal of Medicine in 2021. Researchers eliminated drugs and exercise sessions for everyone and people were left free to lose and regain their weight.

Some people had to face disappointment due to this. People who previously took a weight-loss drug without exercise gained back about 70 percent or more of the weight they had lost since the study began.

Most of this weight gain was in the form of fat but not muscle so the percentage of body fat in such people was relatively higher than before starting the drug.

But people who exercised along with taking the medicine lost a lot of weight during this phase. Many people remained at least 20 percent lighter than at the beginning of the study, and at least some of the weight they gained back was muscle making them have a healthier body composition than the other groups.

exercise only two hours a week

It’s easy to understand why people who exercised added fewer pounds after stopping the drug. “Those people were still exercising even without the monitoring or pressure of scientists. they generally continued to work out several hours a week voluntarily.

This suggests that “about two hours of vigorous exercise a week” may be a good option for preventing weight gain after stopping weight loss medications. A mixture of aerobic and resistance exercise is probably the best option.

Among those who did not exercise at all while taking the drug the majority reported fatigue during and after treatment

Overall the results make a very strong case for “the importance of incorporating exercise into a regimen that includes a GLP-1 drug” said Daniel Drucker MD diabetes specialist and senior investigator at the Lunenfeld-Tannenbaum Research Institute in Toronto. 1 Pave the way for medicines.

studies will be needed to find out whether a less intense exercise routine has the same effect on weight loss when people stop taking the GLP-1 drug.

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